Original Research

Cardiotoxic effects of pavetamine extracted from Pavetta harborii in the rat

L. Hay, R.A. Schultz, P.J. Schutte
Onderstepoort Journal of Veterinary Research | Vol 75, No 3 | a100 | DOI: https://doi.org/10.4102/ojvr.v75i3.100 | © 2008 L. Hay, R.A. Schultz, P.J. Schutte | This work is licensed under CC Attribution 4.0
Submitted: 10 September 2008 | Published: 10 September 2008

About the author(s)

L. Hay,
R.A. Schultz,
P.J. Schutte,

Full Text:

PDF (216KB)

Abstract

Previous studies have shown that crude extracts from Pavetta harborii as well as dried plant material have cardiotoxic effects on rats and sheep that can lead to heart failure. The active component has since been isolated and identified. This substance has been named pavetamine. The aim of this study was to determine whether pavetamine has cardiotoxic effects similar to those seen in previous reports, when administered to rats intraperitoneally. Sprague Dawley rats received two doses, initially 4 mg / kg and then 3 mg / kg pavetamine respectively and were monitored for 35 days before cardiodynamic parameters were measured by inserting a fluid-filled catheter into the left ventricle via the right carotid artery. These values were compared to those of control rats that had received only saline. Pavetamine significantly reduced systolic function and body mass in the treated rats, which indicates that it has the potential to induce heart failure in this animal model.

Keywords

No related keywords in the metadata.

Metrics

Total abstract views: 4859
Total article views: 4092

 

Crossref Citations

1. Cytotoxicity and ultrastructural changes in H9c2(2-1) cells treated with pavetamine, a novel polyamine
C.E. Ellis, D. Naicker, K.M. Basson, C.J. Botha, R.A. Meintjes, R.A. Schultz
Toxicon  vol: 55  issue: 1  first page: 12  year: 2010  
doi: 10.1016/j.toxicon.2008.11.017

2. An evaluation of the endophytic colonies present in pathogenic and non-pathogenic Vanguerieae using electron microscopy
S.L. Stanton, J.J.M. Meyer, C.F. Van der Merwe
South African Journal of Botany  vol: 86  first page: 41  year: 2013  
doi: 10.1016/j.sajb.2013.01.007

3. Damage to some contractile and cytoskeleton proteins of the sarcomere in rat neonatal cardiomyocytes after exposure to pavetamine
C.E. Ellis, D. Naicker, K.M. Basson, C.J. Botha, R.A. Meintjes, R.A. Schultz
Toxicon  vol: 55  issue: 6  first page: 1071  year: 2010  
doi: 10.1016/j.toxicon.2009.12.006

4. The effects of an aqueous leaf extract of Clausena anisata (Willd.) Hook.f.ex Benth. on blood pressure, urine output, angiotensin II levels and cardiac parameters in spontaneously hypertensive rats
MacDonald Tshepo Lechaba Ntamo, Jacobus Schutte Paul, Hay Leon, B ouml hmer Linde, Megandran Govender Melvin
Journal of Medicinal Plants Research  vol: 10  issue: 28  first page: 425  year: 2016  
doi: 10.5897/JMPR2016.6135

5. Total synthesis of ent-pavettamine
Memory Zimuwandeyi, Manuel A Fernandes, Amanda L Rousseau, Moira L Bode
Beilstein Journal of Organic Chemistry  vol: 17  first page: 1440  year: 2021  
doi: 10.3762/bjoc.17.99