Original Research

Comparative histopathology of the lymph nodes, spleen, liver and kidney in experimental ovine trypanosomosis

S.O. Omotainse, V.O. Anosa
Onderstepoort Journal of Veterinary Research | Vol 76, No 4 | a21 | DOI: https://doi.org/10.4102/ojvr.v76i4.21 | © 2009 S.O. Omotainse, V.O. Anosa | This work is licensed under CC Attribution 4.0
Submitted: 09 September 2009 | Published: 09 September 2009

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S.O. Omotainse,
V.O. Anosa,

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The infection of Yankassa rams with three important trypanosome species affecting livestock, namely, Trypanosoma congolense, T. vivax and T. brucei produced both acute and chronic fatal conditions. Chronic infections were induced in the three infections by the application of subcurative doses of diaminazene aceturate (Berenil®). Pathological changes in the infected animals included splenomegaly and hepatomegaly which were more pronounced in acute than in chronic T. congolense infection. However, these changes were more severe in chronic than in acute T. vivax infection. While splenomegaly was more pronounced in chronic T. brucei infection than in acute, hepatomegaly and lymphadenopathy were more severe in acute than in the chronic condition. The increases in size of the spleen, lymph nodes and liver were associated with congestion, increases in cell density related to increased immunological reactions in the spleen and lymph nodes as well as increase in numbers, size and activity of the phagocytic cells in these organs.


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