Original Research

Histomorphometrical and ultrastructural study of the effects of carbendazim on the magnum of the Japanese quail (Coturnix coturnix japonica)

Wahabu H. Kimaro, Mary-Catherine Madekurozwa, Herman B. Groenewald
Onderstepoort Journal of Veterinary Research | Vol 80, No 1 | a579 | DOI: https://doi.org/10.4102/ojvr.v80i1.579 | © 2013 Wahabu H. Kimaro, Mary-Catherine Madekurozwa, Herman B. Groenewald | This work is licensed under CC Attribution 4.0
Submitted: 20 February 2013 | Published: 19 July 2013

About the author(s)

Wahabu H. Kimaro, Department of Anatomy and Physiology, University of Pretoria, South Africa and Department of Veterinary Anatomy, Sokoine University of Agriculture, Tanzania
Mary-Catherine Madekurozwa, Department of Anatomy and Physiology, University of Pretoria, South Africa
Herman B. Groenewald, Department of Anatomy and Physiology, University of Pretoria, South Africa

Abstract

The study investigated the effect of various doses of carbendazim on the morphology of the magnum of the Japanese quail. No morphological changes were observed in the magnum in birds treated with carbendazim at doses of 25 mg/kg and 100 mg/kg bodyweight. A carbendazim dose of 400 mg/kg bodyweight was the lowest dose which caused morphological changes in the magnum. Histologically, carbendazim caused pyknosis and glandular atrophy in the magnum mucosa. Carbendazim also caused significant decreases in the height of the mucosal folds, epithelial height, glandular width and glandular luminal diameter at 400 mg/kg and 800 mg/kg (p < 0.05). At ultrastructural level, dose-dependent deciliation was observed. Pyknotic nuclei, dilated cisternae of rough endoplasmic reticulum, swollen mitochondria, numerous vacuoles and lysosomes in the luminal and glandular epithelia were identified. The observed degenerative changes could be due to cytoskeletal disruption caused by carbendazim toxicity. Degeneration of the luminal and glandular cells in the magnum pose a potential threat to the egg production and reproduction of exposed birds.

Keywords

carbendazim; magnum; morphometry; ultrastructure; Japanese quail

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