Original Research

Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep

S. R. Gooneratne, C. T. Eason, L. Milne, D. G. Arthur, C. Cook, M. Wickstrom
Onderstepoort Journal of Veterinary Research | Vol 75, No 2 | a11 | DOI: https://doi.org/10.4102/ojvr.v75i2.11 | © 2008 S. R. Gooneratne, C. T. Eason, L. Milne, D. G. Arthur, C. Cook, M. Wickstrom | This work is licensed under CC Attribution-NoDerivatives 4.0
Submitted: 30 August 2008 | Published: 31 August 2008

About the author(s)

S. R. Gooneratne, Cell Biology Group, Agriculture and Life Sciences Division, P.O. Box 84, Lincoln University, Lincoln 7647, Qanterbury, New Zealand, New Zealand
C. T. Eason, CENTOX (Centre for Environmental Toxicology), Landcare Research, P.O. B ox 69, Lincoln 7647, New Zealand, New Zealand
L. Milne, CENTOX (Centre for Environmental Toxicology), Landcare Research, P.O. B ox 69, Lincoln 7647, New Zealand, New Zealand
D. G. Arthur, Lab Works Animal Health Ltd, P.O. B ox 11 3, Lincoln University, New Zealand, New Zealand
C. Cook, Hort+Research, Ruakura Research Centre, Hamilton, New Zealand, New Zealand
M. Wickstrom, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, Canada

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Abstract

Acute and long-term effects of a single, relative lyhigh oral dose (0.25a nd 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of sheep were evaluated to establish a better understanding of 1080 poisoning and identify more specific changes diagnostic of toxicosis. In survivors, clinical signs of acute 1080 toxicosis such as salivation and lethar gywere generally very mild. Fasted animals were more prone to 1080 toxicity. In animals that died, more severe signs, including tachypnoea, dyspnoea, and tremors occurred for 15-20 min prior to death. 1080 concentrations were highest in the blood> heart> skeletal muscle> liver. 1080 could not be detected in any of these organs of the animals that survived. Serum citratec oncentratione were elevated for 4 days after dosing. No clinical or biochemical abnormalities were found in any animal after 4 days. Histopathological lesions were most marked in the heart and lung with inflammation, necrosis, and scattered foci of fibrous tissue in the myocardium, pulmonary oedema and inflammation of the lung. No adverse longterm effects on general health or reproductive performance were observed in any sheep that survived the first 4 days following exposure to 1080. The most reliable diagnostic in dicators of 1080 exposure in sheep were measurement of its residues in blood, skeletal muscle and ruminal contents, increased serum citratec oncentratione; l evated heart rate,and characteristic electrocardiograpchh anges(up to 4 days after exposure). Death from 1080 is most likely to occur within 96 h, and animals that survived this period appeared normal.

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Crossref Citations

1. An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California
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