Original Research

Peste des petits ruminants virus infection of Black Bengal goats showed altered haematological and serum biochemical profiles

Shahana Begum, Mohammed Nooruzzaman, Murshida Parvin, Nijaya Mohanto, Rokshana Parvin, Mohammad R. Islam, Emdadul H. Chowdhury
Onderstepoort Journal of Veterinary Research | Vol 85, No 1 | a1595 | DOI: https://doi.org/10.4102/ojvr.v85i1.1595 | © 2018 Shahana Begum, Mohammed Nooruzzaman, Murshida (Mst.) Parvin, Nijaya Mohanto, Rokshana Parvin, Mohammad R. Islam, Emdadul H. Chowdhury | This work is licensed under CC Attribution-NoDerivatives 4.0
Submitted: 07 December 2017 | Published: 15 October 2018

About the author(s)

Shahana Begum, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Mohammed Nooruzzaman, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Murshida Parvin, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Nijaya Mohanto, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Rokshana Parvin, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Mohammad R. Islam, Department of Pathology, Bangladesh Agricultural University, Bangladesh
Emdadul H. Chowdhury, Department of Pathology, Bangladesh Agricultural University, Bangladesh


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Abstract

In Bangladesh, veterinarians often claim to reduce the mortality of natural peste des petits ruminants (PPR) outbreaks with the help of supportive fluid and electrolyte therapy. Information on haematological and biochemical parameters of PPR-infected goats, which is often altered because of associated tissue damages, is necessary to formulate the appropriate supportive therapy. This study determined the haematological and serum biochemical parameters of Black Bengal goats naturally infected with PPR virus. Blood and serum samples from 13 PPR-affected Black Bengal goats from 13 field outbreaks and 5 healthy goats were collected and analysed by routine haematological and biochemical examination. Haematological analysis of PRR-affected goats showed severe anaemia characterised by significant decrease in the values of haemoglobin, total erythrocyte counts (TECs) and packed cell volume (PCV). On the contrary, PPR-affected goats showed marked leucocytosis with absolute increase in lymphocytes and neutrophils counts compared to the healthy goats. Biochemical analysis revealed significant decrease in total protein and albumin level and increased creatine kinase, aspartate transaminase and alanine transaminase that mirrored the gross and histopathological changes in the PPR-affected goats. Significant increase in the values of sodium and chloride ions was found in the sera of PPR-infected goats. Peste des petits ruminants virus altered the haematological and serum biochemical parameters of the infected goats. Antidiarrheal agents with aqua solution together with other drugs to support liver and kidney function could help improve therapy of PPR-infected goats.

Keywords

PPR; haematology; biochemical analysis; electrolyte imbalance; goats

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