Original Research

Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens

Tülin G. Gökmen, Hatice Yazgan, Yıldız Özdemir, Sedat Sevin, Nevin Turut, Şifa Karahan, Funda Eşki, İbrahim Kıvrak, Osman Sezer, Armağan E. Ütük
Onderstepoort Journal of Veterinary Research | Vol 90, No 1 | a2097 | DOI: https://doi.org/10.4102/ojvr.v90i1.2097 | © 2023 Tülin G. Gökmen, Hatice Yazgan, Yıldız Özdemir, Sedat Sevin, Nevin Turut, Şifa Karahan, Funda Eşki, İbrahim Kıvrak, Osman Sezer, Armağan E. Ütük | This work is licensed under CC Attribution 4.0
Submitted: 21 December 2022 | Published: 20 July 2023

About the author(s)

Tülin G. Gökmen, Department of Microbiology, Ceyhan Veterinary Faculty, Cukurova University, Adana, Turkey
Hatice Yazgan, Department of Food Hygiene and Technology, Ceyhan Veterinary Faculty, Cukurova University, Adana, Turkey
Yıldız Özdemir, Microbiology Laboratory, Adana City Hospital, Adana, Turkey
Sedat Sevin, Department of Pharmacology and Toxicology, Veterinary Faculty, Ankara University, Ankara, Turkey
Nevin Turut, Microbiology Laboratory, Veterinary Control Institute, Adana, Turkey
Şifa Karahan, Microbiology Laboratory, Veterinary Control Institute, Adana, Turkey
Funda Eşki, Department of Obstetrics and Gynecology, Veterinary Faculty, Cukurova University, Adana, Turkey
İbrahim Kıvrak, Department of Chemistry and Chemical Processing Technologies/Cosmetic Technology Program, Muğla Vocational School, Muğla Sıtkı Koçman University, Muğla, Turkey
Osman Sezer, Parasitology Laboratory, Veterinary Control Institute, Adana, Turkey
Armağan E. Ütük, Department of Parasitology, Ceyhan Veterinary Faculty, Cukurova University, Adana, Turkey

Abstract

Bee venom with an antimicrobial effect is a powerful natural product. One of the most important areas where new antimicrobials are needed is in the prevention and control of multi-drug resistant pathogens. Today, antibacterial products used to treat multi-drug resistant pathogen infections in hospitals and healthcare facilities are insufficient to prevent colonisation and spread, and new products are needed. The aim of the study is to investigate the antibacterial effect of the bee venom (BV), a natural substance, on the species of Methicillin resistant Staphylococcus aureus, Vancomycin resistant Enterococcus faecalis, Carbapenem resistant Escherichia coli, Carbapenem resistant Klebsiella pneumoniae and Carbapenem resistant Acinetobacter baumannii. As a result of this study, it was found that MIC90 and MBC90 values ranged from 6.25 μg/mL – 12.5 μg/mL and numbers of bacteria decreased by 4–6 logs within 1–24 h for multi-drug resistant pathogens. In particular, Vancomycin resistant Enterococcus faecalis isolate decreased 6 log cfu/mL at 50 μg/mL and 100 μg/mL concentrations in the first hour. The effective bacterial inhibition rate of bee venom suggests that it could be a potential antibacterial agent for multi-drug resistant pathogens.

Contribution: The treatment options of antibiotic-resistant pathogens are a major problem in both veterinary and human medicine fields. We have detected a high antibacterial effect against these agents in this bee venom study, which is a natural product. Apitherapy is a fashionable treatment method all over the world and is used in many areas of health. Bee venom is also a product that can be used as a drug or disinfectant raw material and can fill the natural product gap that can be used against resistant bacteria.


Keywords

bee venom; multi-drug resistant pathogens; antibacterial activity; microdilution method; bioproduct

Sustainable Development Goal

Goal 3: Good health and well-being

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